Life Expectancy With Chronic Kidney Disease (2024)

Chronic kidney disease (CKD) is a condition with many stages and can affect a person's life expectancy. It occurs when the kidneys become damaged and can no longer adequately filter blood. When the kidneys don't function properly, waste can build up in the body, causing various symptoms and problems.

Kidney disease can worsen over time and lead to kidney failure, which affects life expectancy. Early diagnosis can help prevent further damage to the kidneys.

Chronic kidney disease is a slow, progressive disease diagnosed in stages. Stages 1 and 2 indicate mild damage to the kidneys, while stages 3, 4, and 5 reflect more serious progression that affects prognosis and life expectancy.

This article explains stages 3, 4, and 5 of CKD, life expectancy at each stage, and how to cope with the disease.

Prognosis of Chronic Kidney Disease

The most typical progression of chronic kidney disease is that it progresses through stages 1-5 of the disease. Although the disease usually gets worse, treatment can slow the progression significantly.

Once the disease has progressed to stage 3, there is more data about how a person moves through the stages of kidney disease. Some people's disease will never progress beyond stage 3. The time it takes to move from stage 3 to stage 5 is highly variable, but it can take quite a long time, especially with lifestyle changes, medication, and other treatments.

Chronic Kidney Disease Stages

The stages of chronic kidney disease range from mild to severe. In the early stages (1 and 2), kidney damage is mild. The kidneys still work fairly well, and symptoms may not occur. The only indication of kidney damage may be in specific blood or urine tests.

Chronic kidney disease’s effect on life expectancy depends on the amount of damage to the kidneys. However, it decreases life expectancy at every age and stage. Preventing further damage to the kidneys and other conditions (such as heart disease) is critical to having the best life expectancy.

The later stages of CKD occur when damage to the kidneys becomes more apparent. Symptoms often appear in these stages.

Stage 3 Kidney Disease

Stage 3 kidney disease is separated into two sub-stages: stage 3a and stage 3b. These substages are based on an eGFR blood test, which measures how well the kidneys filter waste.

An eGFR between 45 and 59 indicates stage 3a. Kidney damage in this stage is mild to moderate. Symptoms include:

• Swelling in the hands and feet
• Weakness
• Feeling tired

An eGFR between 30 and 44 indicates stage 3b. Kidney damage is moderate to severe, and symptoms may progress. Other health problems, such as high blood pressure and bone disease, may also occur.

In one study, about half of people with stage 3 did not progress to stage 4 or 5. Treatment and healthy lifestyle changes to protect the kidneys can slow the progression of CKD.

Stage 4 Kidney Disease

Stage 4 indicates severe kidney damage with an eGFR of 15-29. Symptoms can include:

• Swelling in the arms and legs
• Muscle cramps
• Nausea
• Vomiting
• Loss of appetite

Other health problems can develop because of the buildup of waste in the body. These include:

• Anemia (when there are not enough healthy red blood cells in the blood)
• Heart disease
• Metabolic acidosis (a condition where there is too much acid in the body)
• High blood pressure

Stage 4 is the last stage before kidney failure. Treatment includes blood pressure and diabetes medicines, diuretics (water pills), iron supplements to help with anemia and supplements like calcium and vitamin D.

In some cases, dialysis, a treatment to help the body filter the blood, may become necessary.

Stage 5 Kidney Disease/End-Stage Renal Disease

Stage 5, end-stage renal disease, is indicated by an eGFR of less than 15. Damage to the kidneys is severe. The kidneys have failed. The symptoms and concurrent health issues such as high blood pressure and anemia from stage 4 can all occur in stage 5 as well.

At this stage, you will need to see a nephrologist or kidney doctor to develop a treatment plan and monitor your kidney health.

Treatment options in this stage include dialysis or kidney transplant, along with blood pressure medications, diabetes medications, and other medications to treat symptoms.

Chronic Kidney Disease Life Expectancy by Stage

Life expectancy with CKD depends on the person's age and the stage at which diagnosis occurs. Having more kidney damage at an earlier age can reduce life expectancy more than being diagnosed later in life with less kidney damage.

Stage 3 Kidney Disease Life Expectancy

Life expectancy for stage 3 kidney disease depends on the diagnosis age. One study found that the life expectancy for men and women diagnosed with stage 3a at the age of 40 was a little more than 24 years.

On the other hand, the same study found that being diagnosed with stage 3a at age 60 resulted in a life expectancy of 10 years.

Stage 4 Kidney Disease Life Expectancy

Stage 4 kidney disease is associated with more significant damage to the kidneys. At this stage, the disease has progressed quite far.

The life expectancy for someone diagnosed with stage 4 at any age is significantly lower than the average life expectancy. One study found that the life expectancy for someone aged 70 who enters stage 4 kidney disease is about four years.

As with any such figure, many factors, such as newer treatments, might not be reflected in past studies.

Stage 5 Kidney Disease/ESRD Life Expectancy

Stage 5 kidney disease, or end-stage renal disease, carries a much lower life expectancy than all other stages. At this stage, the kidneys have failed.

The damage to the kidneys cannot be undone. While dialysis and kidney transplant are options in this stage that can prolong life, life expectancy is relatively low.

Coping With Chronic Kidney Disease

Living well with chronic kidney disease is possible. Knowing the signs and symptoms, understanding the causes, seeking early diagnosis, and following a treatment plan can all help you live a longer, healthier life with CKD.

Signs and Symptoms of CKD

In the early stages of CKD, there may not be symptoms. Though there may be damage to the kidneys, the damage is not enough to cause symptoms. As CKD progresses, symptoms develop.

Symptoms include but aren’t limited to:

• Swelling in the legs, feet, and ankles.
• Skin that is dry, itchy, or numb
• Fatigue
• Headaches
• Urinating more or less
• Nausea
• Lack of appetite
• Sleep problems
• Vomiting
• Weight loss

Causes of Chronic Kidney Disease

Diabetes and high blood pressure are the two most common causes of chronic kidney disease. In diabetes, high blood sugar can damage the filters in the kidneys, making them unable to function the way they should.

High blood pressure can cause damage to the blood vessels in the kidneys and affect their ability to function.

Other causes of CKD include:

• Diseases that affect the entire body, such as lupus (an autoimmune inflammatory disease)
• Genetic disorders like polycystic kidney disease (in which there are multiple cysts in the kidneys)
• An infection
• Drugs that are toxic to the kidneys
• IgA glomerulonephritis (a buildup of an immune system protein in the filters of the kidney)
• Heavy metal poisoning
• Renal artery sclerosis (narrowing of one of the arteries that supply the kidney)

Diagnosing Chronic Kidney Disease

Diagnosis of chronic kidney disease is important because the earlier the diagnosis is made, the earlier treatment can begin to help protect the kidneys.

Those at higher risk for developing chronic kidney disease should talk to their healthcare provider about when to test for kidney disease. Having diabetes, high blood pressure, heart disease, or a family history of kidney failure can all put you at a higher risk for developing kidney disease.

Early chronic kidney disease often does not have symptoms. Diagnosing the disease requires medical tests. These tests include the eGFR blood test to check kidney function and urine tests that check for protein.

Treatment of Chronic Kidney Disease

The goal of treating and managing chronic kidney disease is to limit or prevent further damage to the kidneys. Preventing further damage to the kidneys can slow progression to later stages of CKD which in turn can improve life expectancy.

Steps taken to manage CKD can also improve overall health. These include:

• Controlling blood pressure
• Managing blood sugar levels if you have diabetes
• Taking medications as prescribed
• Working with a dietitian to devise an eating plan that will support and protect the kidneys
• Exercising
• Getting enough sleep
• Stopping smoking
• Reducing stress

Dialysis and kidney transplant are used to treat end-stage kidney disease. Dialysis allows people with end-stage kidney disease to prolong life by years or even decades. Dialysis is also an option for those who are waiting for a kidney transplant.

A kidney transplant is one of the best options for end-stage renal disease. Long-term survival and quality of life increase with a transplant. However, a transplant does carry risks in the short term due to the possibility of infection and organ rejection.

Summary

Life expectancy with chronic kidney disease depends on the age at which you enter each stage. There are five stages of CKD, with stages 3, 4, and 5 being the most severe.

Seeking early diagnosis and treatment for CKD can improve life expectancy. Treatment options are available. Dialysis and kidney transplant can lead to a longer and better quality of life.